cTCrosstalk - Prioritising targets at the crosstalk level from input SNPs

Error Message: your input at Step 1
  • Please check your input SNP identifiers (dbSNP rsIDs) and p-values (between 0 and 1); otherwise they will be ignored.
  • Please paste your own data at Step 1 every time before clicking the Submit button. Notably, the text box at Step 1 is always pre-filled with the provided example when the interface page is first-visited or refreshed.


  cTCrosstalk - Prioritising pathway crosstalk & Performing drug repurposing ... (please don't refresh this page)
Show Info  Example I/O

Step 1: Paste your SNPs here (1st column for dbSNP rsIDs, 2nd for significance info).

Step 2: Include SNPs in Linkage Disequilibrium (LD) defined by which population.

Step 3: Define core genes based on genomic proximity, quantitative trait locus (QTL) and promoter capture Hi-C (PCHi-C).

Step 4: Network core and peripheral genes using knowledge of protein interactions.

Step 5: Identify the crosstalk mediating molecular pathways with the desired number of genes.

SNP significance (SNPs with intolerable significance will be ignored).
Restarting probability (controlling network influential range that the walker will explore starting from core genes).
Manhattan plot (top prioritised genes to be labelled).
Target pathways (based on top prioritised genes).

Prioritisation results (interactive)   Explore  Download