Intratumoral heterogeneity of APL blasts follows cellular differentiation hierarchy.
A total of 18 APL cell clusters are identified, each characterized by distinct expression patterns of known marker genes.
A total of 6 APL cell branches are revealed according to the differentiation trajectory from the leukemic stem-like cell cluster to GMP-like cell clusters, including: stem-like, Prog-like, S100hiGMP-like, GMP-like, cycling GMP-like, and MDP-like branches.
PML/RARĪ± targets are significantly enriched in APL-specific leukemic stemness genes.
ATRA induces differentiation of APL primitive blasts towards more mature cells.
ATRA treatment significantly increases the percentages of the more mature GMP-like cell type and decreases the percentages of three primitive cell types (stem-like, Prog-like, and S100hiGMP-like), with stem-like cells almost undetectable after the treatment.
ATRA has a notable impact on primitive APL cells, especially the stem-like cells.
Providing more information about TACH, including key publications behind it.