subtype name rating rank seed nGene eGene cGene description adult onset asthma PTPN6 5 1 N 0 0 0 protein tyrosine phosphatase non-receptor type 6 adult onset asthma PLCG1 4.839367461648384 2 Y 0 1 0 phospholipase C gamma 1 adult onset asthma PTPN11 4.823810267341182 3 Y 1 0 2 protein tyrosine phosphatase non-receptor type 11 adult onset asthma STAT3 4.773211464536214 4 Y 1 2 7 signal transducer and activator of transcription 3 adult onset asthma STAT1 4.44600187478431 5 Y 0 1 0 signal transducer and activator of transcription 1 adult onset asthma HLA-A 4.413990781252751 6 Y 1 66 3 major histocompatibility complex, class I, A adult onset asthma RELA 4.403214932872752 8 Y 0 0 9 RELA proto-oncogene, NF-kB subunit adult onset asthma JAK1 4.316032015154937 11 N 0 0 0 Janus kinase 1 adult onset asthma JUN 4.303766898136884 12 Y 0 1 0 Jun proto-oncogene, AP-1 transcription factor subunit adult onset asthma MAPK3 4.294452734579075 13 N 0 0 0 mitogen-activated protein kinase 3 adult onset asthma AKT1 4.2788162200925335 15 N 0 0 0 AKT serine/threonine kinase 1 adult onset asthma STAT6 4.26824403214442 16 Y 1 21 11 signal transducer and activator of transcription 6 adult onset asthma KRAS 4.251475388357239 18 Y 0 1 0 KRAS proto-oncogene, GTPase adult onset asthma EGFR 4.232821555634101 19 N 0 0 0 epidermal growth factor receptor adult onset asthma HRAS 4.226652163437651 21 N 0 0 0 HRas proto-oncogene, GTPase adult onset asthma IRF4 4.226652163437651 21 Y 1 1 8 interferon regulatory factor 4 adult onset asthma MAPK1 4.214384808740675 25 N 0 0 0 mitogen-activated protein kinase 1 adult onset asthma LCK 4.200191235177449 27 N 0 0 0 LCK proto-oncogene, Src family tyrosine kinase adult onset asthma CREBBP 4.168213007551321 28 Y 0 0 6 CREB binding protein adult onset asthma ESR1 4.161629978290257 29 N 0 0 0 estrogen receptor 1 adult onset asthma CD247 4.154419413444422 31 Y 1 5 23 CD247 molecule adult onset asthma TYK2 4.134915271267733 33 N 0 0 0 tyrosine kinase 2 adult onset asthma INS 4.132977628483382 34 N 0 0 0 insulin adult onset asthma IFNG 4.13039767254449 35 N 0 0 0 interferon gamma adult onset asthma EP300 4.110539544722327 37 Y 0 3 6 E1A binding protein p300 adult onset asthma SHC1 4.0991180945217565 38 Y 0 0 1 SHC adaptor protein 1 adult onset asthma CD80 4.077757080932706 40 Y 1 0 0 CD80 molecule adult onset asthma JAK2 4.075885413913678 41 Y 0 0 2 Janus kinase 2 adult onset asthma TP53 4.031582502316854 46 Y 0 0 1 tumor protein p53 adult onset asthma NFKB1 4.023706227845144 48 Y 1 13 26 nuclear factor kappa B subunit 1 adult onset asthma FYN 4.015866412224065 51 N 0 0 0 FYN proto-oncogene, Src family tyrosine kinase adult onset asthma SRC 4.011659923389675 52 Y 0 1 0 SRC proto-oncogene, non-receptor tyrosine kinase adult onset asthma STAT2 3.930771260152478 60 Y 0 1 3 signal transducer and activator of transcription 2 adult onset asthma HSP90AA1 3.890575119481738 65 Y 0 0 1 heat shock protein 90 alpha family class A member 1 adult onset asthma MAPK14 3.8463491291068395 71 Y 0 1 0 mitogen-activated protein kinase 14 adult onset asthma IRF3 3.7121470045258347 81 N 0 0 0 interferon regulatory factor 3 adult onset asthma CREB1 3.707076251161873 82 N 0 0 0 cAMP responsive element binding protein 1 adult onset asthma FOS 3.704040296980154 83 Y 0 1 0 Fos proto-oncogene, AP-1 transcription factor subunit adult onset asthma HLA-C 3.69596806059477 84 Y 1 71 9 major histocompatibility complex, class I, C adult onset asthma IFNB1 3.6954646812645606 85 N 0 0 0 interferon beta 1 adult onset asthma HLA-B 3.6934524930095303 86 Y 1 38 6 major histocompatibility complex, class I, B adult onset asthma HLA-E 3.6919447446543394 88 Y 1 5 18 major histocompatibility complex, class I, E adult onset asthma MAPK8 3.6859256354989833 90 N 0 0 0 mitogen-activated protein kinase 8 adult onset asthma HLA-DRA 3.633559390367682 104 Y 1 19 45 major histocompatibility complex, class II, DR alpha adult onset asthma PTPRC 3.619475462221084 106 Y 1 1 11 protein tyrosine phosphatase receptor type C adult onset asthma PRKCQ 3.5873172465756444 110 Y 1 6 2 protein kinase C theta adult onset asthma HLA-DRB1 3.55895405306704 111 Y 1 102 31 major histocompatibility complex, class II, DR beta 1 adult onset asthma ZAP70 3.522669344483591 127 N 0 0 0 zeta chain of T cell receptor associated protein kinase 70 adult onset asthma HLA-F 3.491554610000901 131 Y 0 25 7 major histocompatibility complex, class I, F adult onset asthma IRF7 3.380981691745032 168 N 0 0 0 interferon regulatory factor 7 adult onset asthma HLA-DQA1 3.2667420251532784 225 Y 1 81 19 major histocompatibility complex, class II, DQ alpha 1 adult onset asthma CD8A 3.263059340556146 226 Y 0 1 0 CD8a molecule adult onset asthma HLA-G 3.1049407446357704 314 Y 1 51 3 major histocompatibility complex, class I, G childhood onset asthma PTPN6 5 1 N 0 0 0 protein tyrosine phosphatase non-receptor type 6 childhood onset asthma PTPN11 4.787524778726702 3 N 0 0 0 protein tyrosine phosphatase non-receptor type 11 childhood onset asthma PLCG1 4.666317225119187 8 N 0 0 0 phospholipase C gamma 1 childhood onset asthma STAT6 4.422854404407127 9 Y 1 18 11 signal transducer and activator of transcription 6 childhood onset asthma JUN 4.419387242788855 10 N 0 0 0 Jun proto-oncogene, AP-1 transcription factor subunit childhood onset asthma EGFR 4.183887051140034 15 N 0 0 0 epidermal growth factor receptor childhood onset asthma RELA 4.160325102876393 16 Y 0 0 2 RELA proto-oncogene, NF-kB subunit childhood onset asthma AKT1 4.148346908571577 17 N 0 0 0 AKT serine/threonine kinase 1 childhood onset asthma STAT1 4.081954837347389 19 Y 0 1 0 signal transducer and activator of transcription 1 childhood onset asthma MAPK3 4.066012791720731 21 N 0 0 0 mitogen-activated protein kinase 3 childhood onset asthma NFKB1 4.049599304548304 22 N 0 0 0 nuclear factor kappa B subunit 1 childhood onset asthma ESR1 4.046991028482799 23 N 0 0 0 estrogen receptor 1 childhood onset asthma LCK 4.040491595127748 24 N 0 0 0 LCK proto-oncogene, Src family tyrosine kinase childhood onset asthma HSP90AA1 4.000223299331861 25 N 0 0 0 heat shock protein 90 alpha family class A member 1 childhood onset asthma STAT3 3.9758577418349184 27 N 0 0 0 signal transducer and activator of transcription 3 childhood onset asthma SRC 3.928334713540974 28 N 0 0 0 SRC proto-oncogene, non-receptor tyrosine kinase childhood onset asthma IRF4 3.877675937359029 29 N 0 0 0 interferon regulatory factor 4 childhood onset asthma MAPK1 3.834306138057795 33 N 0 0 0 mitogen-activated protein kinase 1 childhood onset asthma JAK2 3.8326196548896294 34 Y 0 0 2 Janus kinase 2 childhood onset asthma JAK1 3.8314963800417723 35 N 0 0 0 Janus kinase 1 childhood onset asthma EP300 3.816969298849724 36 N 0 0 0 E1A binding protein p300 childhood onset asthma FYN 3.8058885835459835 37 N 0 0 0 FYN proto-oncogene, Src family tyrosine kinase childhood onset asthma CREBBP 3.7828778011747195 38 N 0 0 0 CREB binding protein childhood onset asthma KRAS 3.7812473184162956 39 N 0 0 0 KRAS proto-oncogene, GTPase childhood onset asthma HRAS 3.754857149877024 44 N 0 0 0 HRas proto-oncogene, GTPase childhood onset asthma IFNG 3.7389186374111834 45 N 0 0 0 interferon gamma childhood onset asthma SHC1 3.734695701294364 46 N 0 0 0 SHC adaptor protein 1 childhood onset asthma MAPK8 3.700798282458504 49 N 0 0 0 mitogen-activated protein kinase 8 childhood onset asthma TYK2 3.673177769372154 51 N 0 0 0 tyrosine kinase 2 childhood onset asthma TP53 3.671150640427714 52 N 0 0 0 tumor protein p53 childhood onset asthma ACTB 3.6345954825054645 62 N 0 0 0 actin beta childhood onset asthma FOS 3.633605458343696 63 N 0 0 0 Fos proto-oncogene, AP-1 transcription factor subunit childhood onset asthma PIK3CA 3.6296513499509238 64 Y 0 0 7 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha childhood onset asthma NRAS 3.6105104765231424 68 N 0 0 0 NRAS proto-oncogene, GTPase childhood onset asthma PTEN 3.5906246808439377 72 N 0 0 0 phosphatase and tensin homolog childhood onset asthma CBL 3.585810414184464 73 N 0 0 0 Cbl proto-oncogene childhood onset asthma MAP2K1 3.565265705863846 81 N 0 0 0 mitogen-activated protein kinase kinase 1 childhood onset asthma IL4 3.5496674211942403 84 Y 1 1 8 interleukin 4 childhood onset asthma GRB2 3.5365442981149497 86 N 0 0 0 growth factor receptor bound protein 2 childhood onset asthma MAPK14 3.5027969796405705 101 N 0 0 0 mitogen-activated protein kinase 14 childhood onset asthma PIK3R1 3.4882093257272153 106 N 0 0 0 phosphoinositide-3-kinase regulatory subunit 1 childhood onset asthma IL10 3.480057221488324 113 N 0 0 0 interleukin 10 childhood onset asthma STAT5A 3.4723927786427624 116 N 0 0 0 signal transducer and activator of transcription 5A childhood onset asthma UBC 3.46789988901433 118 N 0 0 0 ubiquitin C childhood onset asthma TNF 3.4288475022105587 133 Y 0 0 20 tumor necrosis factor childhood onset asthma PLCG2 3.368842171012538 161 N 0 0 0 phospholipase C gamma 2 childhood onset asthma IRS1 3.302514607285337 219 N 0 0 0 insulin receptor substrate 1 childhood onset asthma RHOA 3.3008757352529647 221 N 0 0 0 ras homolog family member A childhood onset asthma SOS1 3.276864012364771 233 N 0 0 0 SOS Ras/Rac guanine nucleotide exchange factor 1 childhood onset asthma RXRA 3.0488407768671286 356 N 0 0 0 retinoid X receptor alpha