Pathway crosstalk

An interactive table for pathway crosstalk genes, with the column Rating for priority rating and the column Rank for the priority rank. The column Type tells the target gene type (either Core for core genes or Peripheral for peripheral genes). Also provided is a summary of evidence, including columns Proximity (evidence of genomic proximity), QTL (e/pQTL evidence) and PCHiC (conformation evidence).

Single-node removal

An interactive table for crosstalk genes (the column Crosstalk genes), together with an index for drugs (see the column PIC2Drug; ranged 0-1) measured by the effect-by-removal analysis (here the effect on the crosstalk estimated after removing the single node/gene). If targeted by phase 3 or approved drugs (see the column Phase), the information on repurposed drugs is also detailed; see the column Drug info, formatted as drugs [mechanisms of action] (disease indications). The column PIC2Target shows the index for targets (scored 0-5).